Physical Coating of Mesoporous Silica Nanoparticles with Poly (2-vinyl pyridine) and Polyvinylpyrrolidone for the adsorption and release of 5- Fluorouracil

Authors

  • Syahidah Onn
  • Nur Hidayatul Nazirah Kamarudin
  • Nur Syazaliyana Azali
  • Jafreena Adira Jaafar
  • Sharifah Najiha Timmiati
  • Herma Dina Setiabudi

DOI:

https://doi.org/10.11113/mjcat.v4n1.141

Keywords:

MSN, Poly (2-vinyl pyridine), Polyvinylpyrrolidone, 5-Fluorouracil, Adsorption, Drug release

Abstract

Nanotechnology is now being used in various application such as drug carrier, waste water treatment, internal air cleaner, catalyst, bio-catalyst etc. Currently, nanotechnology is widely used in medical application due to the disadvantage in conventional drug delivery which leaves side effects to the patient. Nanotechnology has the potential to improve the treatment methods. In this study, 5-fluorouracil (5-Fu) is used as model drug to evaluate the adsorption and release from drug carrier which is mesoporous silica nanoparticles (MSN). MSN is modified with pH-sensitive polymer which are poly (2-vinyl pyridine) (P2VP) and polivinylpyrrolidone (PVP). Modified MSN were characterized by using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). Through the analysis, the results obtained prove that there is a cross-linkage between MSN molecules and polymers. Based on the result for drug loading, along 6 hours of experiment, the highest percentage of drug loading is at 80ºC which are 99.53%. and 99.29% for MSN-P2VP and MSN-PVP. Meanwhile, for drug release, the experiment was conducted at 37ºC for 72 hours. As a result, percentage of drug release for MSN-P2VP-5-Fu and MSN-PVP-5-Fu were 95.55% and 90.63%. It can be concluded that MSN-P2VP and MSN-PVP show slow release and could be recommended for further study in drug delivery.

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Published

2020-06-21

How to Cite

Onn, S., Kamarudin, N. H. N., Azali, N. S., Jaafar, J. A., Timmiati, S. N., & Setiabudi, H. D. (2020). Physical Coating of Mesoporous Silica Nanoparticles with Poly (2-vinyl pyridine) and Polyvinylpyrrolidone for the adsorption and release of 5- Fluorouracil. Malaysian Journal of Catalysis, 4(1). https://doi.org/10.11113/mjcat.v4n1.141

Issue

Vol. 4 No. 1 (2020): Vol 4, No 1 (2020)

Section

Research Article

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